Charles V1500 - 1558 Born Sat, 24 February 1500 Prinsenhof, Ghent Died Sun, 21 September 1558 Monastery of Yuste, Cuacos de Yuste Buried El Escorial, San Lorenzo de El Escorial Details Parents Holy Roman Emperor Karl Lived 58 years, 6 months, 28 days father Philip the Handsome 1478 - 1506 mother Joanna of Castile 1479 - 1555 Siblings Sister Eleanor of Austria 1498 - 1558 Sister Isabella of Austria 1501 - 1526 Brother Ferdinand I 1503 - 1564 Sister Mary of Hungary 1505 - 1558 Sister Catherine of Austria 1507 - 1578